Molecular Inversion Probe (MIP)
Ideal as target enrichment technique for NGS application
Extraordinary high specificity in multiplex reactions
- High capture reproducability
- Bias reduction: no fragmentation and PCR needed
- Straight forward and easily automatable
What is a Molecular Inversion Probe?
The advances in DNA analysis made a great leap forward with the emergence of Next Generation Sequencing (NGS). With these advances different target enrichment techniques have been developed to select the regions of interest for NGS analysis in a sensitive and cost-effective way. Amongst these techniques a solution phase “capture by circularization” method using “Molecular Inversion Probes” (MIPs) has gained increasing interest. Extensively used for research in Single Nucleotide Polymorphisms (SNPs) and Copy Number Variation (CNV), now the MIPs have shown multiple advantages as a Genomic partitioning technique allowing enrichment for regions of interest at a scale that is matched by Next Generation Sequencing platforms.
More about Molecular Inversion Probes
Download our whitepaper to learn more about Molecular Inversion Probes.